Epilepsy can be a complex disorder.

Types of Seizures

Seizures happen when your nerve cells fire much more frequently and with less control than usual.

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Seizures can affect your movements, your senses, your concentration, your ability to communicate—even consciousness itself. After most types of seizures, even brief ones, you may feel confused for some time.

Most epileptic seizures are either partial seizures, which affect just one part of the brain, or generalized seizures, which affect both sides of the brain at the same time.

Seizures differ in many ways, both in the form they take and in the way they make you feel. Some people experience only one type of seizure; others experience more than one type, or a combination. Part of taking control of your seizures is to learn all you can about how they happen and what treatments can help you to prevent them. You’ll find brief descriptions of the different seizure types listed below.

Partial Seizures

Partial seizures (also called focal seizures) affect just one part of your brain. Partial seizures can interfere with your awareness and your ability to communicate; they can also make your body move in ways that you can’t control.

Partial seizures are the most common type of seizure. A partial seizure can stimulate your emotions and your senses, make your body move, interfere with your perceptions, generate perceptions, and produce vivid, extended hallucinations that you can see or hear.

Sometimes a partial seizure will trigger a generalized seizure. In medical language, this is called a partial seizure secondarily generalized.

Simple Partial Seizures

During a simple partial seizure, you remain conscious, though you may not be able to move or communicate. Parts of your body may move, twitch, or shake. You may feel nauseated; your skin may flush, go pale, or get goose bumps. Your own body, and the things and the space around you, may seem warped and unfamiliar, and you may experience sensations, sights, sounds, smells, and tastes caused only by your seizure.

You may feel a powerful sense of déjà vu, and visions from your past may seem to appear. You may also have a burst of extreme emotion, which—however wonderful or wrenching or scary it may seem at the time—is just another part of your seizure.

Despite all this, when it is all over—since you have been conscious the entire time—your memory of the event may be quite clear.

Complex Partial Seizures

During a complex partial seizure, although your eyes may stay open and you may move around, you will probably be unconscious. If you can speak, your words are unlikely to make sense. You will be unable to control how you move or what you say and do.

A complex partial seizure may begin with a blank stare and a loss of consciousness and continue through a number of events, some of which may include mumbling and other movements of the mouth; mechanical, repetitive activities; wandering around or going through seemingly routine tasks; talking or crying out; disturbed reactions, as if you were having a nightmare; and various agitated motions—all just part of your seizure.

When you emerge from a complex partial seizure, you will have no memory of what has taken place.

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Generalized Seizures

Generalized seizures affect both sides of the brain at the same time from the time the seizure begins. You lose consciousness—often for a very short time, but sometimes for two to three minutes.

Absence Seizures

An absence seizure (also known as petit mal) can happen so quickly that it can sometimes go unnoticed. Absence seizures begin suddenly and end suddenly, without any prior warning or aftereffect. You experience a sudden—but fleeting—loss of awareness, sometimes accompanied by staring.

Absence seizures are more commonly experienced by children, though adults also have them. With some absence seizures your eyelids or facial muscles will twitch, or certain muscles may go slack. When an absence seizure lasts longer than usual, automatic movements can also occur.

Atonic Seizures

During an atonic seizure (also known as a drop attack, an astatic seizure or an akinetic seizure), some of your muscles suddenly go limp. Your head may fall to your chest, your legs buckle, your posture slip and droop; you may even collapse. Because there’s no warning—and no time to position yourself or prevent a fall—you may hit your head or face. Atonic seizures are not easy to control with medicines. If you are subject to atonic seizures, you may need to wear headgear to protect yourself from injury.

Myoclonic Seizures

During a myoclonic seizure, your muscles contract rapidly for a brief time. You make sudden jerking motions on both sides of your body or sometimes in one foot or arm. While you probably will not need first aid, you should see a healthcare professional if you’ve just had a myoclonic seizure for the first time.

Tonic-Clonic Seizures

During a tonic-clonic seizure (also known as grand mal or convulsions), you stiffen (the tonic phase) and your limbs and face begin to jolt and shake (the clonic phase). During the tonic phase, your breathing may slow down or even pause. In a typical tonic-clonic seizure, when the convulsive movements begin, breathing returns. The jerking and jolting of the clonic phase often lasts less than a minute.

Tonic-clonic seizures occur in different ways. Some people experience only the initial stiffening; others experience only the jerking motions. For some people, a tonic-clonic seizure may begin with an atonic seizure.

The muscles that control continence may be among those that contract and relax rapidly during the clonic phase. Although you may bite your tongue or parts of your mouth during a tonic-clonic seizure, you cannot "swallow your tongue" as some myths insist.

After a tonic-clonic seizure, you may feel confused and thoroughly exhausted; you may also have a headache. Your body and your brain will need rest. Expect it to take a little while—from a few minutes to some hours—to feel entirely yourself again.

If breathing does not return quickly after the tonic phase, if a seizure goes on for more than 5 minutes, or if another seizure or series of seizures follows the first, you will need emergency medical care.

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Nonepileptic Seizures

Some people have brief episodes that resemble epileptic seizures, yet they are not caused by electrical disturbances in the brain. Although sometimes difficult for an observer to distinguish from a true epileptic seizure, these nonepileptic seizures have nothing to do with epilepsy.

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Status Epilepticus

Most seizures are brief. But when your seizures go on for too long or come in clusters, you are at risk for a condition called status epilepticus—an ongoing state of seizure or multiple seizures with continued loss of consciousness. If this happens to you, you will need emergency treatment. If you’re identified to be at risk for status epilepticus, work with your healthcare professional to ensure that you have a plan of action in place that will get you immediate treatment in case of a seizure emergency.

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About Syndromes

Healthcare professionals use the word syndrome to describe a set of symptoms that tend to appear together under similar circumstances and respond to certain treatments.

Lennox-Gastaut syndrome, for example, is one of the most severe forms of epilepsy; it accounts for up to 10% of all cases of childhood epilepsy. It usually develops in children between 1 and 8 years of age, with 3 the average age of onset. (For more, see About Lennox-Gastaut syndrome.)

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Learn More About Seizures and Syndromes

For more on seizures and syndromes, visit the page on Seizures and Epilepsy at the Web site of the National Institute of Neurological Disorders and Stroke (NINDS) or the Epilepsy Foundation’s Answer Place. Please see our Important Organizations and Resources page or click here to learn more about TOPAMAX for Epilepsy.


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About TOPAMAX®

TOPAMAX® is approved as initial monotherapy in patients 2 years of age and older with partial-onset or primary generalized tonic-clonic seizures.

Safety and effectiveness in patients who were converted to monotherapy from a previous regimen of other anticonvulsant drugs have not been established in controlled trials.

TOPAMAX® is approved as add-on therapy for patients 2 years of age and older with primary generalized tonic-clonic seizures, partial-onset seizures, or seizures associated with Lennox-Gastaut syndrome.

Important Safety Information

Warnings and Precautions

TOPAMAX ® may cause eye problems. Serious eye problems include: sudden decrease in vision with or without eye pain and redness; blockage of fluid in the eye causing increased pressure in the eye (secondary angle closure glaucoma). These eye problems can lead to permanent loss of vision if not treated. You should call your healthcare professional right away if you have any new eye symptoms.

TOPAMAX ® may cause decreased sweating and increased body temperature (fever). People, especially children, should be watched for signs of decreased sweating and fever, especially in hot temperatures. Some people may need to be hospitalized for this condition. Call your healthcare provider right away if you have a fever or decreased sweating.

TOPAMAX ® can increase the level of acid in your blood (metabolic acidosis). If left untreated, metabolic acidosis can cause brittle or soft bones (osteoporosis, osteomalacia, osteopenia), kidney stones, can slow the rate of growth in children, and may possibly harm your baby if you are pregnant. Metabolic acidosis can happen with or without symptoms. Sometimes people with metabolic acidosis will: feel tired, not feel hungry (loss of appetite), feel changes in heartbeat, or have trouble thinking clearly. Your healthcare provider should do a blood test to measure the level of acid in your blood before and during your treatment with TOPAMAX ®. If you are pregnant, you should talk to your healthcare provider about whether you have metabolic acidosis.

Like other antiepileptic drugs, TOPAMAX ® may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Pay attention to any changes and call your doctor right away if you have any of these symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying, attempts to commit suicide, new or worse depression, new or worse anxiety, feeling agitated or restless, panic attacks, trouble sleeping (insomnia), new or worse irritability, acting aggressive, being angry or violent, acting on dangerous impulses, an extreme increase in activity and talking (mania), or other unusual changes in behavior or mood.

TOPAMAX ® may affect how you think, and cause confusion, problems with concentration, attention, memory, or speech, depression or mood problems, tiredness, and sleepiness.
Do not stop taking TOPAMAX ® without first talking to your doctor. Stopping TOPAMAX ® suddenly can cause serious problems.

If you take TOPAMAX ® during pregnancy, your baby has a higher risk for birth defects called cleft lip and cleft palate. These defects can begin early in pregnancy, even before you know you are pregnant. There may be other medicines to treat your condition that have a lower chance of birth defects. All women of childbearing age should talk to their healthcare providers about using other possible treatments instead of TOPAMAX ®. If the decision is made to use TOPAMAX ®, you should use effective birth control (contraception) unless you are planning to become pregnant. Tell your healthcare provider right away if you become pregnant while taking TOPAMAX ®. You and your healthcare provider should decide if you will continue to take TOPAMAX ® while you are pregnant. Metabolic acidosis may have harmful effects on your baby. Talk to your healthcare provider if TOPAMAX ® has caused metabolic acidosis during your pregnancy. If you become pregnant while taking TOPAMAX ®, talk to your healthcare provider about registering with the North American Antiepileptic Drug Pregnancy Registry. You can enroll in this registry by calling 1-888-233-2334. The purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy.

TOPAMAX ® may cause high blood ammonia levels. High ammonia in the blood can affect your mental activities, slow your alertness, make you feel tired, or cause vomiting.

Taking TOPAMAX ® when you are also taking valproic acid can cause a drop in body temperature (hypothermia) to less than 95ºF, feeling tired, confusion, or coma.

Adverse Reactions

As monotherapy, the most common side effects of TOPAMAX ® (in the 400 mg/day group and at a higher rate, ≥ 5%, than the 50 mg/day group) in adults were tingling in arms and legs, weight decrease, loss of appetite, sleepiness, and difficulty with memory; and in children, fever, weight decrease, mood problems, cognitive problems, infection, flushing, and tingling in arms and legs.

In combination with other antiepileptic drugs (AEDs), the most common side effects of TOPAMAX ® in adults (200 to 400 mg/day) were sleepiness, dizziness, loss of muscle coordination, speech disorders and related problems, psychomotor slowing, abnormal vision, difficulty with memory, tingling in arms and legs, and double vision; and in children (5 to 9 mg/kg/day), fatigue, sleepiness, loss of appetite, nervousness, difficulty with concentration/attention, difficulty with memory, aggressive reaction, and weight decrease.

Tell your doctor about other medications that you are taking. Report any side effect that bothers you or that does not go away.

These are not all the possible side effects of TOPAMAX ®. For more information, ask your healthcare professional or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full US Prescribing Information and Medication Guide.

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This site was last modified on: Feb 13 2012 at 11:05:00 EST